2-(8-Fluoro-imidazo[1,2-a]pyridin-7-yl)-propan-2-ol synthesis
- Product Name:2-(8-Fluoro-imidazo[1,2-a]pyridin-7-yl)-propan-2-ol
- CAS Number:628322-91-8
- Molecular formula:C10H11FN2O
- Molecular Weight:194
17282-04-1
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Yield:-
Steps:
Multi-step reaction with 4 steps
1.1: lithium diisopropylamide / tetrahydrofuran / -78 °C
1.2: 95 percent / tetrahydrofuran / -78 - 20 °C
2.1: Cs2CO3; BINAP; Pd(OAc)2 / toluene / 95 °C
3.1: aq. HBr / 90 °C
4.1: propan-2-ol / 50 °C
References:
Humphries, Alexander C.;Gancia, Emanuela;Gilligan, Myra T.;Goodacre, Simon;Hallett, David;Merchant, Kevin J.;Thomas, Steve R. [Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,# 6,p. 1518 - 1522]
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628322-91-8
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