(3aS,8aR)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole synthesis
- Product Name:(3aS,8aR)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole
- CAS Number:65166-97-4
- Molecular formula:C14H20N2O
- Molecular Weight:232.32
![Pyrrolo[2,3-b]indole, 1,2,3,3a,8,8a-hexahydro-5-methoxy-3a,8-dimethyl-, (3aS,8aR)-](/CAS/20210305/GIF/104069-11-6.gif)
Yield:65166-97-4 92%
Reaction Conditions:
Stage #1: formaldehyd;(3aS,8aR)-5-methoxy-3a,8-dimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole in methanol;water at 0; for 0.0833333 h;Inert atmosphere;
Stage #2: with sodium tris(acetoxy)borohydride in methanol;water at 20; for 1.5 h;Inert atmosphere;
References:
Nakao, Yoshiaki;Ebata, Shiro;Yada, Akira;Hiyama, Tamejiro;Ikawa, Masashi;Ogoshi, Sensuke [Journal of the American Chemical Society,2008,vol. 130,p. 12874 - 12875] Location in patent:supporting information; experimental part
![(3aS,8aR)-5-Bromo-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indole](/CAS/20210305/GIF/139066-02-7.gif)
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