3-METHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID synthesis
- Product Name:3-METHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID
- CAS Number:6577-89-5
- Molecular formula:C10H11NO3
- Molecular Weight:193.2
7272-58-4
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Yield:6577-89-5 97%
Reaction Conditions:
Stage #1: ethyl 3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylatewith sodium hydroxide in ethanol; for 1 h;Reflux;
Stage #2: with hydrogenchloride in water;
References:
Barraja, Paola;Diana, Patrizia;Montalbano, Alessandra;Carbone, Anna;Cirrincione, Girolamo;Viola, Giampietro;Salvador, Alessia;Vedaldi, Daniela;Dall'Acqua, Francesco [Bioorganic and Medicinal Chemistry,2008,vol. 16,# 22,p. 9668 - 9683] Location in patent:experimental part