一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List TERT-BUTYL 6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[1,3-BENZOXAZINE-2,4'-PIPERIDINE]-1'-CARBOXYLATE
690632-05-4

TERT-BUTYL 6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[1,3-BENZOXAZINE-2,4'-PIPERIDINE]-1'-CARBOXYLATE synthesis

1synthesis methods
6329-74-4 Synthesis
5-BROMOSALICYLAMIDE

6329-74-4
97 suppliers
$6.00/1g

79099-07-3 Synthesis
N-(tert-Butoxycarbonyl)-4-piperidone

79099-07-3
0 suppliers
$5.00/5g

-

Yield:690632-05-4 63%

Reaction Conditions:

with pyrrolidine at 72; for 2 h;Microwave irradiation;

Steps:



Three batches of 5-bromo salicylamide (4, 5.00g each, 23.1mmol), N-Boc-piperidin-4-one (3.45g, 17.3mmol) and pyrrolidine (1.64g, 23.1mmol) were heated in different flasks at 72°C under MW irradiation for 1h. Further N-Boc-piperidin-4-one (3.45g, 17.3mmol) was added and the mixtures were heated for 1h at 72°C. The resulting precipitates were collected by filtration and washed with MeOH to give the spirocycle 5 (17.2g, 63%) as a white solid. 1H NMR (300MHz, DMSO-d6): δ=8.86 (s, 1H), 7.82 (d, J=2.35Hz, 1H), 7.69 (dd, J=8.66, 2.49Hz, 1H), 7.06 (d, J=8.80Hz, 1H), 3.64-3.88 (m, 2H), 3.02-3.21 (m, 2H), 1.91-2.10 (m, 2H), 1.63-1.78 (m, 2H), 1.40ppm (s, 9H).

References:

Thaler, Florian;Varasi, Mario;Abate, Agnese;Carenzi, Giacomo;Colombo, Andrea;Bigogno, Chiara;Boggio, Roberto;Zuffo, Roberto Dal;Rapetti, Daniela;Resconi, Anna;Regalia, Nickolas;Vultaggio, Stefania;Dondio, Giulio;Gagliardi, Stefania;Minucci, Saverio;Mercurio, Ciro [European Journal of Medicinal Chemistry,2013,vol. 64,p. 273 - 284]

TERT-BUTYL 6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[1,3-BENZOXAZINE-2,4'-PIPERIDINE]-1'-CARBOXYLATE Related Search:

彩票| 永靖县| 大竹县| 商水县| 白银市| 静乐县| 项城市| 准格尔旗| 垣曲县| 三都| 封开县| 桑日县| 丁青县| 米易县| 高邑县| 手机| 浏阳市| 铜川市| 襄垣县| 红桥区| 柳河县| 旌德县| 花莲县| 拉孜县| 太仓市| 和硕县| 凉山| 犍为县| 阿瓦提县| 深泽县| 泌阳县| 太白县| 紫云| 滦平县| 泾阳县| 长岭县| 佳木斯市| 合山市| 濉溪县| 维西| 松滋市|