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ChemicalBook CAS DataBase List 7-Aminoindole
5192-04-1

7-Aminoindole synthesis

4synthesis methods
7-Nitroindole

6960-42-5

7-Aminoindole

5192-04-1

The general procedure for the synthesis of 7-aminoindoles using 7-nitroindoles as starting material is as follows: 7-nitroindoles were dissolved in ethanol according to the method described in Scheme VII (step A). To this solution was added ammonium formate (10 equivalents) and a catalytic amount of 10% palladium carbon. Subsequently, the reaction mixture was heated to reflux for 1 hour. Upon completion of the reaction, it was cooled to room temperature, filtered through a diatomaceous earth pad to remove the catalyst, and the filtrate was concentrated under reduced pressure to give 7-aminoindole in purple solid form in 99% yield.

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