7-CHLORO-4-QUINAZOLINOL synthesis
- Product Name:7-CHLORO-4-QUINAZOLINOL
- CAS Number:31374-18-2
- Molecular formula:C8H5ClN2O
- Molecular Weight:180.59
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The general procedure for the synthesis of 7-chloro-4(3H)-quinazolinone from formamidine acetate and 2-amino-4-chlorobenzoic acid was as follows: 10 g of 2-amino-4-chlorobenzoic acid (BB1) and 8 g of formamidine acetate (1.3 eq.) were added to a 100 ml eggplant flask and mixed thoroughly. The mixture was placed in a microwave reactor and reacted at 60% power for 4 min. After completion of the reaction, it was cooled to room temperature, 30 ml of water was added, stirred and the solid product was collected by filtration. The resulting product was 7-chloro-4(3H)-quinazolinone (BB2) in a yield of 10 g with 95% yield.
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Yield: 95%
Reaction Conditions:
in waterMicrowave irradiation;
Steps:
3.4.2
10g of compound BB1, formamidine acetate 8g (1.3eq) into 100ml eggplant-shaped flask, uniformly mixed, the microwave reaction 4πη (60% power). After cooling, 30ml of water was added, the solid was washed and filtered to give the BB2 compound 10g, yield 95%.
References:
SHANGHAIINSTITUTES FOR BIOLOGICAL SCIENCES, CAS;ShanghaiInstitute of Materia Medica (SIMM), Chinese Academy of Sciences (CAS),;WANG, HUI;LIU, HONG;LI, XIAOGUANG;ZHANG, XU;LIU, YANLING;GONG, NUOXI;CHEN, KERONG CN103570738, 2016, B Location in patent:Paragraph 0303; 0304; 0306
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$13.00/1g
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$13.00/1g
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31374-18-2
171 suppliers
$13.00/1g
89-77-0
433 suppliers
$6.00/10g
31374-18-2
171 suppliers
$13.00/1g