7-Hydroxyquinolinone synthesis
- Product Name:7-Hydroxyquinolinone
- CAS Number:70500-72-0
- Molecular formula:C9H7NO2
- Molecular Weight:161.16
22246-18-0
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70500-72-0
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Yield:70500-72-0 90.9%
Reaction Conditions:
with palladium 10% on activated carbon in decalin at 180; for 8 h;
Steps:
1-7 Example 2:
100 g of 3,4-dihydro-7-hydroxy-2-quinolinone was added to a 3000 mL reaction flask, 2000 mL of decalin was added, and 10 g of 10% palladium carbon was finally added. The mixture was heated to 180 °C, stirred under reflux for 8 hours, cooled to room temperature, and 400 mL of a 2 mol/L sodium hydroxide solution was added thereto and the catalyst was filtered off. The separated aqueous layer was further added with 80 ml of a 10 mol/L hydrochloric acid solution and dried by filtration to obtain 89.7 g of an off-white powder of 7-hydroxy-2-quinolinone in a yield of 90.9%, purity (HPLC) 98.9%.
References:
Shanghai Pharmaceutical Industry Institute;China Pharmaceutical Industry Zongyuan;Zheng Zhiwei;Sui Qiang;Jiang Kaiyuan;Tang Chao;Gao Qi;Liu Shuai;Chen Jianli;Li Gen CN109776408, 2019, A Location in patent:Paragraph 0030-0043; 0047; 0048
127033-74-3
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70500-72-0
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15116-41-3
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70500-72-0
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591-27-5
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70500-72-0
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536-90-3
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70500-72-0
429 suppliers
$6.00/250mg