7-OCTYN-1-OL synthesis
- Product Name:7-OCTYN-1-OL
- CAS Number:871-91-0
- Molecular formula:C8H14O
- Molecular Weight:126.2
20739-58-6
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$40.00/5mL
871-91-0
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$30.00/1g
Yield:871-91-0 91%
Reaction Conditions:
with sodium hydride;Trimethylenediamine in hexane;mineral oil at 0 - 20; for 3 h;
Steps:
Alkyne-Zipper Reaction of 2-Octyn-1-ol (25) Using NaH
A dry hexane solution of 1,3-propanediamine (3.78 g,51.5 mmol, 6.5 eq.) was treated with commercial NaH(50 wt% in mineral oil, 1.98 g, 41.2 mmol, 5.2 eq.) at 60 °Cfor 10 min, and then the reaction mixture was treated with2-octyn-1-ol (25, 1.00 g, 7.92 mmol) at 0 °C to room temperaturefor 3 h. The reaction was then quenched by additionof methanol and water, and the reaction mixture wasextracted with chloroform. The organic layer was washedwith water and was dried over anhydrous Na2SO4powder,and then the organic solvent was evaporated in vacuo. Thecrude products were purified by column chromatography onsilica gel to obtain 7-octyn-1-ol (26, 1.22 g, 91% yield) [54]as pale yellow oil.
References:
Shimada, Kazuaki;Sugawara, Ayako;Korenaga, Toshinobu;Kawashima, Hideki [Lipids,2017,vol. 52,# 12,p. 1019 - 1032]
14916-80-4
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871-91-0
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$30.00/1g
10297-09-3
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871-91-0
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119837-87-5
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871-91-0
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16695-31-1
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871-91-0
163 suppliers
$30.00/1g