1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE HYDROCHLORIDE 98 synthesis
- Product Name:1-BENZYL-4-CYANO-4-HYDROXYPIPERIDINE HYDROCHLORIDE 98
- CAS Number:71617-20-4
- Molecular formula:C13H17ClN2O
- Molecular Weight:252.7399
71617-20-4
48 suppliers
$22.00/5g
1262988-77-1
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$41.00/100mg
Yield:1262988-77-1 96%
Reaction Conditions:
with hydrogenchloride;water for 16 h;Reflux;
Steps:
4.1
Step 11-Benzyl-4-hydroxy-piperidine-4-carboxylic acid, hydrochloride A mixture of 8 g (32 mmol) 1-benzyl-4-cyano-4-hydroxypiperidine hydrochloride and 15.8 mL HCl (37%) was heated to reflux for 16 h. The solution was cooled to room temperature and the white precipitate was filtered off and washed with iso-propanol. The filtrate was evaporated to yield 9.71 g (96%) of the title compound as white waxy solid which was used without further purification. MS (m/e): 234.4[(MH)-].
References:
US2011/28515,2011,A1 Location in patent:Page/Page column 17
71617-20-4
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$22.00/5g
27771-25-1
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$111.00/500mg