Carbamic acid, (1,3,4-oxadiazol-2-ylmethyl)-, 1,1-dimethylethyl ester (9CI) synthesis
- Product Name:Carbamic acid, (1,3,4-oxadiazol-2-ylmethyl)-, 1,1-dimethylethyl ester (9CI)
- CAS Number:716329-43-0
- Molecular formula:C8H13N3O3
- Molecular Weight:199.21
Yield:716329-43-0 850 mg
Reaction Conditions:
with toluene-4-sulfonic acid at 80; for 4 h;
Steps:
Preparation of tert-butyl ((1 ,3,4-oxadiazol-2-yl)methyl)carbamate.
To a solution of tert-butyl (2-hydrazinyl-2-oxoethyl)carbamate (5.00 g, 26.4 mmol) in trimethoxymethane (50 mL) was added 4-methylbenzenesulfonic acid (45.5 mg, 0.26 mmol) The mixture was stirred at 80°C for 4 hour. The mixture was concentrated. The crude mixture was purified by flash chromatography with petroleum ether:ethyl acetate = 3:1 to give tert-butyl ((1 ,3,4-oxadiazol-2-yl)methyl)carbamate (850 mg).
References:
WO2018/7249,2018,A1 Location in patent:Page/Page column 103
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