一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
77017-20-0

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate synthesis

2synthesis methods
2-((10S,13S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate (1 kg, 2.73 mol), acetone (50 L) and purified water (2.6 L) were added to the reaction vessel, and dissolved by stirring at room temperature; Formic acid (0.4 L, 10.60 mol) and potassium permanganate (1.2 kg, 7.59 mol) were added in that order, and the reaction was stirred at room temperature for 1 h. The reaction was quenched by the addition of saturated sodium hydrogen sulfite solution (10 L) and manganese dioxide, and some solid impurities were removed by suction filtration, and the filtrate was evaporated under reduced pressure to give a large white solid. The filter cake was washed with water to give 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate (1.01 kg, 92.2%).
16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate
-

Yield:77017-20-0 100%

Reaction Conditions:

Stage #1: 21-hydroxypregna-1,4,9(11),16-tetraene-3,20-dione 21-acetatewith formic acid in propan-2-one at 0; for 0.25 h;
Stage #2: with potassium permanganate in propan-2-one at -5 - 5; for 1.5 h;Temperature;

Steps:

1-3

Oxidation reaction: add 20g of tetraene acetate into the reaction flask,600mL acetone,Cool down to 0,Add 6mL formic acid,After 15 minutes of incubation reaction,Add 100 mL of 18% potassium permanganate solution to the reaction vessel,The control temperature of the dripping process does not exceed 5,The dripping is completed within 30 minutes, and the temperature is kept at 0±5 and reacted for 1 hour.After thin layer analysis to no raw material,Then add 80 mL of reducing solution (10% sodium carbonate aqueous solution) into the reactor,Stir and react for 10 minutes,The reaction system was heated to 35°C and filtered,Concentrate the filtrate until there is no acetone smell,Then add 900 mL of water to the filtrate,Cool down to below 5,Let stand for 1 hour,Suction filtration and drying to obtain 20 g of oxide (1),The yield was 100%.

References:

CN113480593,2021,A Location in patent:Paragraph 0023; 0025-0027; 0031-0033; 0037-0039

16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Related Search:

修武县| 乌兰察布市| 鹤壁市| 布尔津县| 新兴县| 苏州市| 温宿县| 长葛市| 通化县| 黎平县| 沁阳市| 邮箱| 竹北市| 绵阳市| 延寿县| 武胜县| 历史| 连江县| 襄樊市| 彩票| 武义县| 新乡县| 荆州市| 麻栗坡县| 南昌县| 安远县| 东乌珠穆沁旗| 舒兰市| 湖口县| 繁昌县| 定远县| 郓城县| 杭锦后旗| 仙桃市| 临清市| 安溪县| 绩溪县| 河北区| 祁连县| 太湖县| 鄯善县|