一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 7,9-DIMETHOXYCARBONYL-2-ETHOXYCARBONYL-1H-PYRROLO-[2,3-F]QUINOLINE-4,5-DIONE
80721-47-7

7,9-DIMETHOXYCARBONYL-2-ETHOXYCARBONYL-1H-PYRROLO-[2,3-F]QUINOLINE-4,5-DIONE synthesis

10synthesis methods
133706-80-6 Synthesis
7,9-DIMETHOXYCARBONYL-2-ETHOXYCARBONYL-5-METHOXY-1H-PYRROLO-[2,3-F]QUINOLINE

133706-80-6
12 suppliers
inquiry

-

Yield:80721-47-7 62%

Reaction Conditions:

with ammonium cerium (IV) nitrate;water in acetonitrile at -5; for 1.58333 h;Cooling with acetone-dry ice;

Steps:

1.I; i

Into a 3-L, 3-neck flask equipped with a mechanical stirrer, a temperature probe, an addition funnel, and a dry ice / acetone bath were placed 5-methoxy-lH pyrrolo[2,3- f]qumoline-2,7,9-tricarboxylic acid 2-ethyl ester 7,9-dimethyl ester (9) (12.09 g, 0.0313 mol) and 600 mL of acetonitrile. The suspension was stirred and cooled to -5 0C. A solution of cerric ammonium nitrate (84.87 g, 0.155 mol) in 120 mL of water was added over a five- minute period. A bright orange solution resulted. Stirring and cooling at -5 0C was continued for 1.5 hours. The reaction mixture was poured into 1380 mL of vigorously-stirred, cold water and stirring was continued for 0.5 hour. The cerrium salts were filtered off and the filtrate was extracted with 3 times with 300 mL of methylene chloride. The methylene chloride solution was dried over 75 g of magnesium sulfate and the solvent removed in vacuo to producel0.15 g of solid. The resulting solid was stirred in a solution of 10 mL of toluene and 10 mL of ethyl acetate. The resulting bright red-orange crystals were collected by filtration and washed with a solution of 3 : 1 ethyl acetate - heptane. The crystals were taken up in 360 mL of methylene chloride and stirred with 5 g of silica gel for one hour. The solution was filtered through Celite 521 and stripped to 7.50 g (62.0%) of the title compound as a red-orange solid.; In step i, 5-methoxy-lH-pyrrolo[2,3-fJquinoline-2,7,9-tricarboxylic acid 2-ethyl ester 7,9-dimethyl ester (9) and acetonitrile were placed in a reaction vessel, cooled and stirred. To this suspension was added a solution of aqueous cerric ammonium nitrate ((NBU)2Ce(NOs)6 or CAN) to produce a bright orange solution which was then poured into cold water. The cerrium salts were collected under vacuum and the filtrate was extracted with CH2Cl2. The organic extracts were dried over magnesium sulfate (MgSO4) and concentrated. The resulting residue was taken up in a solution of toluene-ethyl acetate (EtOAc), and the resulting crystals were collected by filtration, washed with EtO Ac-heptane, taken up in CH2Cl2 and stirred with silica gel for 1 hour, and then filtered through Celite. The solvent was removed to produce 4,5-dioxo-4,5-dihydro-l H-pyrrolo[2,3-f]quinoline-2,7,9- tricarboxylic acid 2-ethyl ester 7,9-dimethyl ester (10).

References:

WO2006/102642,2006,A1 Location in patent:Page/Page column 10; 17; 1/6

宁明县| 琼结县| 百色市| 伊川县| 九龙坡区| 浦东新区| 东方市| 苏州市| 新邵县| 鸡东县| 南开区| 科尔| 文山县| 江津市| 古蔺县| 宜宾市| 民权县| 香港| 福建省| 万宁市| 博兴县| 桂林市| 微山县| 南皮县| 舟山市| 黔西县| 广宗县| 南丹县| 雷山县| 永济市| 军事| 阜新市| 镇坪县| 长阳| 铅山县| 东城区| 潼关县| 伊川县| 砚山县| 马公市| 安化县|