Yield:-

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in methanol;

Steps:

A8.c

c. Preparation of intermediate 32; A mixture of intermediate 31 (0.29 mol) in CH30H (600 ml) was hydrogenated with Pd/C 10% (2 g) as a catalyst. After uptake of H2 ( equivalent), the catalyst was filtered off and the filtrate was evaporated. The residue was dissolved in CH2C12 (300 ml) and then IN HCI was slowly added while the solution was stirred vigorously on an ice bath. After this extraction, the aqueous layer was alkalised'with a 50 % NaOH solution to pH > 10 and the resulting mixture was extracted with CH2C12. The organic layer was separated, dried (MgS04), filtered off and the solvent was evaporated. Yield: 40.0 g of intermediate 32.

References:

WO2005/118578,2005,A1 Location in patent:Page/Page column 51