一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 2-ETHOXY-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE
848243-23-2

2-ETHOXY-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE synthesis

2synthesis methods
3-BROMO-2-ETHOXYPYRIDINE

57883-25-7

Bis(pinacolato)diboron

73183-34-3

2-ETHOXY-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE

848243-23-2

A suspension was prepared in DMSO (100 mL) with 3-bromo-2-ethoxypyridine (28.69 g, 142.0 mmol), bis(pinacolato)diboron (43.3 g, 170.5 mmol) and potassium acetate (41.8 g, 425.9 mmol). The suspension was degassed with nitrogen and [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (5.8 g, 7.93 mmol) was added. The reaction mixture was stirred at 95 °C for 6 hours. After completion of the reaction, the reaction mixture was filtered through an Arbocel pad and washed with ethyl acetate (500 mL). The filtrate was concentrated under vacuum and the crude product was purified by silica gel column chromatography using a 50% cyclohexane solution of ethyl acetate as eluent to afford 2-ethoxypyridine-3-boronic acid pinacol ester as a red oil (34.4 g, 74% yield).1H NMR (400 MHz, CDCl3) data were as follows: δ 1.35 (s, 12H), 1.39 (m, 3H). 4.37 (m, 2H), 6.81 (m, 1H), 7.89 (m, 1H), 8.19 (m, 1H).Results of LCMS analysis: retention time (Rt) = 3.27 min, mass spectrum (MS) m/z 250 [MH]+.

-

Yield:848243-23-2 74%

Reaction Conditions:

with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in dimethyl sulfoxide at 95; for 6 h;Inert atmosphere;

Steps:

B.10 Preparation 10 2-ethoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

A suspension of 3-bromo-2-ethoxypyridine (Preparation 1 1 , 28.69 g, 142.0 mmol), bis(pinacolato)diboron (43.3 g, 170.5 mmol), and potassium acetate (41 .8 g, 425.9 mmol) in DMSO (100 mL) was degassed with nitrogen and [1 ,1 '- bis(diphenylphosphinoferrocene]dichloro palladium (II) (5.8 g, 7.93 mmol) was added and the reaction mixture was stirred for 6 hours at 95 °C. The reaction mixture was filtered through a pad of Arbocel which was washed with ethyl acetate (500 mL). The filtrate was concentrated in vacuo and the crude material was purified by silica gel column chromatography eluting with 50% ethyl acetate in cyclohexane to afford the title compound as a red oil (34.4g, 74%). 1H NMR (400MHz, CDCl3): δ ppm 1 .35 (s, 12H), 1 .39 (m, 3H), 4.37 (m, 2H), 6.81 (m, 1 H), 7.89 (m, 1 H), 8.19 (m, 1 H). LCMS Rt = 3.27 minutes MS m/z 250 [MH]+

References:

WO2013/93688,2013,A1 Location in patent:Page/Page column 44-45

2-ETHOXY-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE Related Search:

孙吴县| 台安县| 梁平县| 金阳县| 屏东县| 金阳县| 教育| 兴文县| 隆子县| 江津市| 阿尔山市| 塘沽区| 金沙县| 华安县| 新化县| 胶南市| 岐山县| 太仓市| 老河口市| 鲁山县| 钟山县| 阿荣旗| 乌海市| 清丰县| 青龙| 稷山县| 栾城县| 彩票| 阿克苏市| 额济纳旗| 天津市| 东兰县| 灌南县| 石楼县| 定日县| 兴国县| 读书| 宁波市| 四川省| 南丰县| 拉孜县|