1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE synthesis
- Product Name:1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE
- CAS Number:85532-75-8
- Molecular formula:C21H21ClN2O
- Molecular Weight:352.86
541-41-3
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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89242-09-1
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85532-75-8
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Yield:-
Reaction Conditions:
with hydrogenchloride;triethylamine in toluene
Steps:
44 N-methyl N-1-(S)-methyl propyl) 1-(2-chloro phenyl) isoquinoline 3-carboxamide
EXAMPLE 44 N-methyl N-1-(S)-methyl propyl) 1-(2-chloro phenyl) isoquinoline 3-carboxamide Operations are carried out as for Example 7, starting from 1.7 g of 1-(2-chloro phenyl) isoquinoline 3-carboxylic acid, 2.1 g of triethylamine, 0.75 g of ethyl chloroformate and 0.96 g of N-methyl 2(S)-butanamine, HCl in 60 ml of toluene. After chromatography and recrystallization in cyclohexane, 0.5 g of N-methyl N-(1-(S)-methyl propyl) 1-(2-chlorophenyl) isoquinoline 3-carboxamide melting at 134° C. is obtained. αD27 =+53.7° (0.5% in CHCl3).
References:
Pharmuka Laboratoires US4499094, 1985, A
124236-61-9
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85532-75-8
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