6-METHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID synthesis
- Product Name:6-METHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID
- CAS Number:869941-96-8
- Molecular formula:C8H7N3O2
- Molecular Weight:177.16
10602-37-6
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869941-96-8
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Yield:869941-96-8 81%
Reaction Conditions:
with hydrogenchloride in water at 95;sealed tube;
Steps:
48
A suspension of 5-amino-1H-pyrazole-4-carboxylic acid (271 mg, 2.1 mmol) and 1,1,3,3-tetraethoxy-2-methyl-propane (prepared accordingly to the procedure described in JACS 126(7), 2004, 2194) (0.5 g, 2.1 mmol) in an aqueous solution of hydrochloric acid (6 M, 1.3 mL) was heated at 95° C. in a sealed tube. The solid material completely dissolved when the temperature reached 82° C. and then a solid precipitate crushed out of solution, stirring was continued for 5 minutes. The resulting mixture was cooled to room temperature and the solid was collected by filtration, rinsed with water and dried in vacuum oven to afford 305.1 mg (81% yield) of 6-methyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid.
References:
US2012/15962,2012,A1 Location in patent:Page/Page column 90
920518-65-6
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41680-34-6
181 suppliers
$14.00/1g
869941-96-8
54 suppliers
$121.00/250mg