6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE synthesis
1synthesis methods
- Product Name:6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
- CAS Number:883-87-4
- Molecular formula:C12H17NO2.ClH
- Molecular Weight:243.73
Yield:79 % ee
Reaction Conditions:
with glucose dehydrogenase;D-Glucose;Amycolatopsis orientalis (Uniprot R4SNK4) imine reductase;NADP in aq. phosphate buffer;N,N-dimethyl-formamide at 30; pH=7.5; for 18 h;Enzymatic reaction;stereoselective reaction;
References:
Aleku, Godwin A.;Man, Henry;France, Scott P.;Leipold, Friedemann;Hussain, Shahed;Toca-Gonzalez, Laura;Marchington, Rebecca;Hart, Sam;Turkenburg, Johan P.;Grogan, Gideon;Turner, Nicholas J. [ACS Catalysis,2016,vol. 6,# 6,p. 3880 - 3889]