ChemicalBook CAS DataBase List 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile synthesis

9synthesis methods

Product Name:1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile
CAS Number:885340-11-4
Molecular formula:C32H34F3N3O4
Molecular Weight:581.63

239463-72-0 Synthesis

5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-7-carbonitrile-1H-indole

239463-72-0
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160969-03-9 Synthesis

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate

160969-03-9
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$6.00/250mg

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile

885340-11-4
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Yield:885340-11-4 88%

Reaction Conditions:

with tetrabutylammonium bromide;potassium carbonate;potassium iodide in lithium hydroxide monohydrate at 80; for 6 h;

Steps:

11.5 Preparation of compound VII

the reaction vessel , adding compound (V) 144.1gPotassium carbonate 66g Tetrabutylammonium bromide , potassium iodide , 3.1g, water 1000ml, heated to 80 degrees C, drop adding compound, VI149.5g , Drop80 degrees Celsius and then react 6 hours , use Ethyl acetate extraction, Organic layer, respectively , Sodium bicarbonate wash , Saturatedsalt water washing , Collection of organic layersuse of anhydrous sodium sulfate , drying, Filtration, filtrate decompression concentration , Oil like thing , compound(VII) 203.0g, yield: 88%.

References:

CN103554003,2016,B Location in patent:Paragraph 0038; 0062-0063

239463-85-5 Synthesis