一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 1’-t-Butoxycarbonyl-5-hydroxy-spiro[chroman-2,4’-piperidin]-4-one
911227-79-7

1’-t-Butoxycarbonyl-5-hydroxy-spiro[chroman-2,4’-piperidin]-4-one synthesis

1synthesis methods
699-83-2 Synthesis
2',6'-Dihydroxyacetophenone

699-83-2
476 suppliers
$6.00/5g

79099-07-3 Synthesis
N-(tert-Butoxycarbonyl)-4-piperidone

79099-07-3
0 suppliers
$5.00/5g

1’-t-Butoxycarbonyl-5-hydroxy-spiro[chroman-2,4’-piperidin]-4-one

911227-79-7
20 suppliers
inquiry

-

Yield:911227-79-7 74%

Reaction Conditions:

with pyrrolidine in methanol;Heating / reflux;

Steps:

11A.11.1

Preparation of 11.2: 2',6'-dihydroxyacetophenone (11.1) (200.Og g, 1.31 mol, 1.0 eq) was added portion wise at room temperature to pyrrolidine (220 mL, 2.0 eq) followed by portion wise addition of l-Boc-4-piperidone (1.2) (262.0 g, 1.31 mo, 1.0 eq). Anhydrous methanol (100 mL) was then added and the red slurry heated to reflux to dissolve all solids. On dissolution the reaction was cooled to room temperature overnight with stirring to form a solid mass. This solid mass was dissolved in ethyl acetate, washed with a IN aqueous solution of hydrochloric acid, a IN aqueous solution of sodium hydroxide and brine, dried over sodium sulfate and filtered. The solvent was evaporated under vacuum. A mixture of hexane and diethyl ether (80:20) (400 mL) was added to the mixture and the resulting precipitate was collected by filtration, washed with hexane and used for the next step without further purification.Yield: 74%.1H NMR (400MHz, CDCl3) 5 11.61 (s, IH), 7.37 (t, IH), 6.49 (d, IH), 6.44 (d, IH), 3.89 (brs, 2H), 3.20 (brm, 2H), 2.73 (s, 2H), 2.02 (d, 2H), 1.64 (m, 2H), 1.46 (s, 9H) Mass Spectral Analysis m/z = 334.0 (M+H)+

References:

WO2006/105442,2006,A2 Location in patent:Page/Page column 152; 351

1’-t-Butoxycarbonyl-5-hydroxy-spiro[chroman-2,4’-piperidin]-4-one Related Search:

太白县| 布拖县| 依安县| 美姑县| 通海县| 淳化县| 阿拉尔市| 青冈县| 江华| 定州市| 巩义市| 诸城市| 崇仁县| 湘潭县| 海盐县| 锡林浩特市| 清水县| 新竹县| 连南| 崇仁县| 长武县| 资溪县| 秦安县| 万州区| 磐安县| 吐鲁番市| 曲靖市| 遵义市| 汤阴县| 洪洞县| 宣武区| 云南省| 常熟市| 玛多县| 许昌县| 桦甸市| 乡城县| 化德县| 炎陵县| 临潭县| 连江县|