3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide synthesis
- Product Name:3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide
- CAS Number:917391-28-7
- Molecular formula:C12H10F3N3O
- Molecular Weight:269.22
641571-12-2
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Yield:917391-28-7 85.4%
Reaction Conditions:
with ammonia;water;dihydrogen peroxide in 1-methyl-pyrrolidin-2-one at 20 - 25; for 1 h;
Steps:
7
Example 7 3-(4-Methyl-imidazol-1-yl)-5-trifluoromethyl-benzamide (XXIII)(XXIII)A solution of 5-(4-methyl-imidazol-1-yl)-3-trifluoromethyl-benzonitril (3.5 g, 13.93 mmol) in NMP (28 imL) is treated with aqueous ammonia (9.8 ml_, 25%) and aqueous hydrogen peroxide (3.5 ml_, 30%). The resulting mixture is stirred for 1 hour at 20-250C and then poured into chilled water (420 ml_). The resulting suspension is filtered and the filter cake is washed with water (50 ml_), and dried in vacuo at 500C to give 3.2 g of the title compound (XXIII) (85.4%) as white crystals (98% area by HPLC).
References:
WO2006/135640,2006,A2 Location in patent:Page/Page column 12; 21
149793-69-1
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