ChemicalBook CAS DataBase List 3,5-Bis(methoxycarbonyl)phenylboronic acid pinacol ester

3,5-Bis(methoxycarbonyl)phenylboronic acid pinacol ester synthesis

10synthesis methods

Product Name:3,5-Bis(methoxycarbonyl)phenylboronic acid pinacol ester
CAS Number:944392-68-1
Molecular formula:C16H21BO6
Molecular Weight:320.15

51760-21-5

73183-34-3

3,5-Bis(methoxycarbonyl)phenylboronic acid pinacol ester

944392-68-1

General procedure for the synthesis of 3,5-dimethoxycarbonylphenylboronic acid pinacol ester from dimethyl 5-bromoisophthalate and pinacol ester of bisboronic acid: dimethyl 5-bromo-1,3-benzenedicarboxylate (5.4 g, 19.8 mmol) and pinacol ester of boronic acid (6.0 g, 29.4 mmol) were added into a 250 mL three-necked flask and anhydrous 1,4-dioxane (50 mL) was added As a solvent, Pd(dppf)2Cl2 (0.2 g, 0.27 mmol) was added under nitrogen protection. The reaction mixture was heated to 100 °C and kept for 12 hours. Upon completion of the reaction, it was cooled to room temperature and the excess 1,4-dioxane was removed by distillation. Water (20 mL) was added and extracted with ethyl acetate (30 mL x 3), the organic phases were combined and dried with anhydrous Na2SO4. After filtration, the filtrate was evaporated to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=94/6) to afford 3,5-dimethoxycarbonylphenylboronic acid pinacol ester (4.59 g, 72% yield) in white powder form.

1459-93-4 Synthesis

1459-93-4
344 suppliers
$11.00/100g

73183-34-3
590 suppliers
$6.00/5g

944392-68-1
96 suppliers
$18.00/100mg

Yield: 99%

Reaction Conditions:

with bis(1,5-cyclooctadiene)diiridium(I) dichloride;1-(4,4'-di-tert-butyl-[2,2'-bipyridin]-6-yl)-2-(dimethyl(phenyl)silyl)-2,3-dihydro-1H-benzo[d][1,3,2]diazaboroleInert atmosphere;Schlenk technique;Sealed tube;

Steps:

4.4. General Procedure for Iridium-Catalyzed arene C-H borylation Using NNB-type Ligand
General procedure: B2pin2, [IrCl(COD)]2 (1.0 mol%), preligand 1 (2.0 mol%), and (hetero)arene (0.2 mmol, ifsolid) were placed in a dried Schlenk flask (15 mL in volume) equipped with a stirring bar. Afterevacuating and refilling the flask with dry nitrogen three times, (hetero)arene (0.2 mmol, if liquid)and methoxycyclopentane (CAPE, 0.5 mL) were added with syringes under a stream of nitrogen.The resulting mixture was stirred at the corresponding temperature for the assigned time. After cooling to room temperature, the reaction mixture was concentrated and then purified by columnchromatography on silica gel to give the target product (The spectra data for the borylated compoundscan be seen in the Supplementary Material).

References:

Ding, Siyi;Wang, Linghua;Miao, Zongcheng;Li, Pengfei [Molecules,2019,vol. 24,# 7,art. no. 1434]

51760-21-5 Synthesis

51760-21-5
191 suppliers
$6.00/1g

73183-34-3
590 suppliers
$6.00/5g

944392-68-1
96 suppliers
$18.00/100mg

References

51839-15-7 Synthesis