tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate synthesis
- Product Name:tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate
- CAS Number:953071-73-3
- Molecular formula:C17H23N3O2
- Molecular Weight:301.38
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Yield: 91%
Reaction Conditions:
in methanol at 20; for 3 h;
Steps:
10
Example 10: Preparation of4-(1H-benzoimidazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester; In a reaction vessel, benzoimidazole(1.1g) and methylalcohol(δmL) were introduced, and di tert-butyldicarbonate(1.2g) was added thereto. The mixture was stirred at room temperature for about 3 hours, and then the mixture was condensed to obtain 4-(1 H-benzoimidazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester(1.5g, yield 91%).1H-NMR, 400 MHz, CDCI3, ppm : 1.63(s, 9H), 1.89(m, 2H), 2.11(d, 2H), 2.87(t, 2H), 3.14(m, 1H), 4.23(s, 2H), 7.22~7.24(m, 2H), 7.41 (s, 1H), 7.72(s,
References:
YUHAN CORPORATION WO2009/102155, 2009, A2 Location in patent:Page/Page column 17-18
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24424-99-5
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95-54-5
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95-54-5
543 suppliers
$9.00/1g
953071-73-3
114 suppliers
inquiry
498-94-2
0 suppliers
$5.00/10g
953071-73-3
114 suppliers
inquiry