2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(Methylthio)-1H-pyrazolo[3,4-d]pyriMidin-3(2H)-one synthesis
- Product Name:2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(Methylthio)-1H-pyrazolo[3,4-d]pyriMidin-3(2H)-one
- CAS Number:955369-56-9
- Molecular formula:C17H19N5O2S
- Molecular Weight:357.43
638218-78-7
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![2-allyl-6-(Methylthio)-1H-pyrazolo[3,4-d]pyriMidin-3(2H)-one](/CAS/GIF/955368-90-8.gif)
955368-90-8
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$25.00/100mg
955369-56-9
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$287.00/100mg
Yield:955369-56-9 74%
Reaction Conditions:
with copper (I) iodide;potassium carbonate;N1,N2-dimethylethane-1,2-diamine in 1,4-dioxane at 80;
Steps:
S1.3 Step-3:
Synthesis of 2-allyl-1-[6-(1-hydroxy-1-methyl-ethyl)-2-pyridyl]-6-methylsulfanyl-pyrazolo[3,4-d]pyrimidin-3-one
Step-3:
Synthesis of 2-allyl-1-[6-(1-hydroxy-1-methyl-ethyl)-2-pyridyl]-6-methylsulfanyl-pyrazolo[3,4-d]pyrimidin-3-one
To a stirred solution of 2-allyl-6-methylsulfanyl-1H-pyrazolo[3,4-d]pyrimidin-3-one (200 mg, 0.90 mmol, 1.0 eq) and 2-(6-bromo-2-pyridyl)propan-2-ol (233 mg, 1.08 mmol, 1.20 eq) in 10 mL of dioxane were added copper iodide (171 mg, 0.90 mmol, 1.0 eq), potassium carbonate (186 mg, 1.35 mmol, 1.5 eq) and N,N'-dimethylethylenediamine (87 mg, 0.99 mmol, 1.1 eq) and stirred at 80° C. for overnight.
After completion of reaction, solvent was removed under reduced pressure; residue was diluted with water and extracted with ethyl acetate (30 mL*3).
Combined organic layer was washed with brine solution, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford crude product, which was purified by flash chromatography to afford 240 mg (74%) of 2-allyl-1-[6-(1-hydroxy-1-methyl-ethyl)-2-pyridyl]-6-methylsulfanyl-pyrazolo[3,4-d]pyrimidin-3-one.
References:
US2019/106427,2019,A1 Location in patent:Paragraph 0252; 0258; 0259
26218-75-7
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955369-56-9
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5909-24-0
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955369-56-9
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49669-13-8
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955369-56-9
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$287.00/100mg
![6-(Methylthio)-1H-pyrazolo[3,4-d]pyriMidin-3(2H)-one](/CAS/GIF/100047-42-5.gif)
100047-42-5
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955369-56-9
45 suppliers
$287.00/100mg