tert-butyl 3-(4-bromophenoxy)azetidine-1-carboxylate synthesis
- Product Name:tert-butyl 3-(4-bromophenoxy)azetidine-1-carboxylate
- CAS Number:960402-39-5
- Molecular formula:C14H18BrNO3
- Molecular Weight:328.2
106-41-2
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Yield:960402-39-5 84.4 %
Reaction Conditions:
with di-isopropyl azodicarboxylate;triphenylphosphine in tetrahydrofuran at 0 - 110;
Steps:
53.1 The first step: Preparation of tert-butyl 3-(4-bromophenoxy)azetidine-1-carboxylate (intermediate 53k)
To 4-bromophenol (2.40g, 13.86mmol)and tert-butyl 3-hydroxyazetidine-1-carboxylate (2g, 11.55mmol) in THF (60mL) solution was added triphenylphosphine (3.98g, 15.17mmol) at one time, then at 0°C DIAD (2.81 g, 13.90 mmol) was added dropwise. After dropping, the reaction was heated to 110° C. and stirred for 5 hours. After the reaction was complete, it was cooled to 25°C, concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (PE:EA=1:08:1) to obtain the target compound as a white solid (3.2g, 84.4%).
References:
CN114716370,2022,A Location in patent:Paragraph 0782-0787
106-41-2
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$13.00/5g
141699-58-3
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960402-39-5
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106-41-2
497 suppliers
$13.00/5g
605655-08-1
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$98.00/250mg
960402-39-5
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460-00-4
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141699-55-0
391 suppliers
$6.00/1g
960402-39-5
35 suppliers
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141699-55-0
391 suppliers
$6.00/1g
960402-39-5
35 suppliers
inquiry