4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE synthesis
- Product Name:4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
- CAS Number:97817-23-7
- Molecular formula:C6H9N3S
- Molecular Weight:155.22
124458-10-2
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97817-23-7
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Yield:97817-23-7 91%
Reaction Conditions:
with formaldehyd;acetic acid in methanol;
Steps:
D.6 2-Amino-4-(2-aminoethyl)thiazole
6. 2-Amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine A solution of 2-amino-4-(2-aminoethyl)thiazole (1.57 g, 11.0 mmol) in methanol (120 ml) was treated with acetic acid (0.15 ml, 2.6 mmol) and formaldehyde (0.89 ml of a 37% aqueous solution, 11 mmol). After ten minutes, the reaction mixture was concentrated in vacuo and subjected to column chromatography (eluant: 95:4:1 chloroform:methanol:concentrated ammonium hydroxide). The product was obtained as a white solid, m.p. 169°-173° (1.547 g, 10.0 mmol, 91% yield). 1 H NMR (DMSO-d6): 6.64 (s, 2H), 3.59 (s, 2H), 2.87 (t, J=6 Hz, 2H), 2.33 (bt, 2H).
References:
US5037834,1991,A
![TERT-BUTYL 2-AMINO-6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE](/CAS/GIF/365996-05-0.gif)
365996-05-0
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97817-23-7
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![Thiazolo[5,4-c]pyridin-2-amine, 5-acetyl-4,5,6,7-tetrahydro-](/CAS/GIF/124458-11-3.gif)
124458-11-3
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97817-23-7
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79099-07-3
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$5.00/5g
97817-23-7
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$55.00/100mg