9951-A3 synthesis
- Product Name:9951-A3
- CAS Number:743461-63-4
- Molecular formula:C29H30ClN3O5
- Molecular Weight:536.02
![Carbamic acid, N-[1,1'-biphenyl]-2-yl-, 1-[3-[[2-chloro-4-(hydroxymethyl)-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester](/CAS/20210111/GIF/743461-62-3.gif)
743461-62-3
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743461-63-4
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Yield:743461-63-4 98%
Reaction Conditions:
Stage #1: biphenyl-2-ylcarbamic Acid 1-[2-(2-Chloro-4-hydroxymethyl-5-methoxy-phenylcarbamoyl)ethyl]piperidin-4-yl Esterwith N-ethyl-N,N-diisopropylamine in dichloromethane at -20; for 0.166667 h;
Stage #2: with sulfur trioxide pyridine complex in dichloromethane; for 6 h;
Steps:
4
Step 3) the resulting 59 g type (4) compound, with 70 g DIPEA and 86 g of dimethyl sulfoxide is dissolved in 300 ml dichloromethane in, for -20 °C stirring for 10 min, after addition of 88 g of sulfur trioxide pyridine, continue to be admitted to the completion of the reaction 6 h, to be after the reaction is complete by adding 200 ml water quenching reaction, after dichloromethane extraction, drying, desolvation to get the yellow solid, crude yield up to 98%
References:
CN106632257,2019,B Location in patent:Paragraph 0072-0077
1251456-87-7
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$371.00/1g
![piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate](/CAS/20180702/GIF/171722-92-2.gif)
171722-92-2
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$52.00/250mg
743461-63-4
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171722-92-2
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743461-63-4
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2401-24-3
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$8.00/1g
743461-63-4
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145742-50-3
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$34.00/100mg
743461-63-4
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