Acetamide, 2-(4-chlorophenoxy)-N-methoxy-N-methyl- synthesis
1synthesis methods
- Product Name:Acetamide, 2-(4-chlorophenoxy)-N-methoxy-N-methyl-
- CAS Number:18232-70-7
- Molecular formula:C10H12ClNO3
- Molecular Weight:229.66
Yield:18232-70-7 94%
Reaction Conditions:
Stage #1: 4-Chlorophenoxyacetic acidwith 1,1'-carbonyldiimidazole in dichloromethane at 0 - 23;
Stage #2: N,O-dimethylhydroxylamine*hydrochloridewith triethylamine in dichloromethane at 0 - 10;
References:
Beutner, Gregory L.;Kuethe, Jeffrey T.;Kim, Mary M.;Yasuda, Nobuyoshi [Journal of Organic Chemistry,2009,vol. 74,# 2,p. 789 - 794] Location in patent:supporting information; experimental part