AcetaMide, N-(3-broMo-2-Methylphenyl)- synthesis
- Product Name:AcetaMide, N-(3-broMo-2-Methylphenyl)-
- CAS Number:67866-91-5
- Molecular formula:C9H10BrNO
- Molecular Weight:228.09
Yield:67866-91-5 91%
Reaction Conditions:
at 20 - 50; for 2.16667 h;
Steps:
A-(3-bromo-2-methylphenvDacetamide (55)
Compound 54 (4 g, 21.5 mmol) was dissolved in 4 mL DMSO, to which Acetic anhydride (8.11 mL, 86.0 mmol) was added dropwise. The reaction mixture was stirred in a water bath (50° C) for 10 min, then stirred for additional 2 h at rt. 36 mL DI water was added to the reaction mixture, the resulting suspension was stirred overnight at rt. After which, the solid was collected via vacuum filtration and washed with small portions of DI water. The product was left in the funnel and air dried to afford Compound 55 (4.48 g, 91%) as a solid, which was used for the next step without further purification.
References:
WO2020/56046,2020,A1 Location in patent:Page/Page column 52
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