Aminodiphenylmethane hydrochloride synthesis
- Product Name:Aminodiphenylmethane hydrochloride
- CAS Number:5267-34-5
- Molecular formula:C13H14ClN
- Molecular Weight:219.71
574-66-3
5267-34-5
In the second step, benzophenone oxime (900 mg) was hydrogenated with a solution of concentrated hydrochloric acid (1.84 mL) in ethanol (50 mL) at atmospheric pressure in the presence of 10% Pd/C catalyst (100 mg). Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst and the filtrate was subsequently concentrated. The concentrated residue was suspended in ethyl acetate and the suspension was filtered again to give the final diphenylmethylamine hydrochloride (2.17 g) as a white solid.
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Yield: 80.3%
Reaction Conditions:
with hydrogenchloride;pyrographite in ethanol;water for 1.5 h;Reflux;
Steps:
6 Example 6 Preparation of benzhydrylamine hydrochloride (III)
The above prepared intermediate (II) 120g, activated carbon 12g, 360ml of absolute ethanol, reflux decolorization, activated carbon and silica were removed by filtration, the filtrate was added concentrated hydrochloric acid 110g, refluxed for 1.5 hours, the reaction was complete. Cooling, crystallization, filtration, washing, drying product 95.3g, yield 80.3%, HPLC purity: 99.93%.
References:
Weihai Disu Pharmaceutical Co., Ltd.;Disha Pharmaceutical Group Co., Ltd.;Wu Ronggui;Men Lianbin;Cui Yangyang;Xu Keling;Xue Fuzhao CN107089918, 2017, A Location in patent:Paragraph 0022
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