Yield:71676-00-1 52%

Reaction Conditions:

in triethylamine;acetone

Steps:

IX N-[1-ethyl 2-pyrrolidylmethyl] 2-methoxy 4-amino 5-methylsulphonyl benzamide
EXAMPLE IX N-[1-ethyl 2-pyrrolidylmethyl] 2-methoxy 4-amino 5-methylsulphonyl benzamide Following the same procedure as in Example I, 129 g of 2-methoxy 4-amino 5-methylsulphonyl benzoic acid dissolved in 526 ml of acetone, in the presence of 53 g of triethylamine, is treated with 57 g of ethyl chloroformate then with 81 g of 1-ethyl 2-aminomethyl pyrrolidine. When the substance formed has been purified, 96 g of N-[1-ethyl 2-pyrrolidyl methyl] 2-methoxy 4-amino 5-methylsulphonyl benzamide is obtained (yield=52%-M.P.=151°-151.5° C.).

References:

Societe d'Etudes Scientifiques et Industrielles de l'Ile de-France US4294828, 1981, A

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