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ChemicalBook CAS DataBase List Amitriptyline hydrochloride
549-18-8

Amitriptyline hydrochloride synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: n-butyllithium; carbon dioxide / tetrahydrofuran; hexane / -50 - 20 °C / 3878.71 Torr / Flow reactor
2: methanol / tetrahydrofuran; toluene / 20 °C / Flow reactor
3: ethanol / 0.01 h / 200 °C / 82508.3 Torr / Flow reactor
4: hydrogenchloride / isopropyl alcohol / 20 °C / Flow reactor

References:

Kupracz, Lukas;Kirschning, Andreas [Advanced Synthesis and Catalysis,2013,vol. 355,# 17,p. 3375 - 3380]

FullText

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