一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Apixaban-d3
1131996-12-7

Apixaban-d3 synthesis

1synthesis methods
1-(4-Hydroxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide

503612-76-8
62 suppliers
inquiry

Apixaban-d3

1131996-12-7
26 suppliers
inquiry

-

Yield: 38.61%

Reaction Conditions:

Stage #1:O-Demethylapixaban with potassium carbonate in acetonitrile at 20; for 0.166667 h;sealed tube;
Stage #2:iodomethane-d3 in acetonitrile at 80; for 6 h;sealed tube;

Steps:

2.2
Step 2; l-(4-A-Methoxyphenyl-7-oxo-6-(4-(2-oxo-l-piperidinyl) phenyl)- 4.5.6.7-tetrahydro-lH-pyrazole-r3. 4-cl pyridine-3-carboxamide:; In sealed tube, a mixture of l-(4-hydroxyphenyl)-7-oxo-6-(4-(2-oxopiperdin-l-yl)phenyl)-4,5,6,7- tetrahydro-lH-pyrazolo[3,4-c]pyridine-3-carboxamide (0.250 g, 0.561 mmol), dry acetonitrile, and potassium carbonate (0.154 g, 1.11 mmol) was stirred at ambient temperature for about 10 minutes. d3-Methyl iodide (97.15 mg, 0.67mmol) was then added. The mixture was heated at about 80 0C for about 6 hours, cooled to ambient temperature, and the solids removed by filtration. The resulting filtrate was concentrated and the resulting pale yellow liquid was purified by preparative ΗPLC on a KROMASIL 100 C-18 (30 x 250 mm) 5μ column (0.01M ammonium acetate / methanol (1 : 1); flow rate 20 mL / min; T / %B: 0 / 30, 10 / 80, 20 / 80, 20.1 / 30; UV: 210 nm; run time = 11.212 minutes). The title compound was purified as an off-white solid (100 mg, yield = 38.61%). mp: 236-240 0C; 1H NMR (400 MHz, CDCl3) δ 1.92-1.94 (m, 4H), 2.53-2.55 (m, 2H), 3.37 (t, J= 7.0, 2H), 3.58-3.59 (m, 2H), 4.11 (t, J= 6.8 Hz, 2H), 5.47 ( br s, IH), 6.84 ( br s, IH), 6.93 (d, J= 9.2 Hz, 2H), 7.25 (d, J= 8.0 Hz, 2H) , 7.33 (d, J= 8.4 Hz, 2H), 7.47 (d, J= 9.2 Hz, 2H); IR (KBr) υ 3454. 3307, 3259, 3180, 3060, 3010, 2949, 2864, 2223, 2074, 1675, 1616, 1510, 1459, 1409, 1298, 1262, 1217, 1155, 1104, 1017, 989 cm"1; MS 463 (M + 1).

References:

AUSPEX PHARMACEUTICALS, INC.;GANT, Thomas, G.;SHAHBAZ, Manoucherhr WO2010/30983, 2010, A2 Location in patent:Page/Page column 34

Apixaban-d3 Related Search:

根河市| 宣化县| 京山县| 林口县| 金昌市| 三门县| 临潭县| 浏阳市| 新巴尔虎左旗| 赤壁市| 滦南县| 余江县| 通山县| 芦溪县| 福泉市| 兴海县| 沂水县| 迁安市| 会同县| 桃江县| 泗水县| 邯郸县| 丽水市| 鄂尔多斯市| 囊谦县| 龙口市| 巧家县| 昭平县| 金山区| 廉江市| 上饶市| 扎兰屯市| 阿鲁科尔沁旗| 南丰县| 山丹县| 峡江县| 平昌县| 扶余县| 涪陵区| 怀安县| 纳雍县|