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ChemicalBook CAS DataBase List Azilsartan Medoxomil
863031-21-4

Azilsartan Medoxomil synthesis

3synthesis methods
Azilsartan medoxomil also known as TAK-491, is an orally administered angiotensin II receptor type 1 antagonist (blocker) used in the treatment of adults with essential hypertension. Azilsartan medoxomil is a useful and attractive new option for lowering BP in patients with essential hypertension, particularly for those not able to tolerate other antihypertensive drugs. Further studies are required to evaluate the effects of azilsartan medoxomil on cardiovascular morbidity and mortality.
Synthetic Routes
  • ROUTE 1

    • 202112075251634904.jpg

    Garaga, Srinivas; Misra, Nimesh C.; Raghava Reddy, Ambati V.; Prabahar, Koilpillai Joseph; Takshinamoorthy, Chandiran; Sanasi, Paul Douglas; Babu, Korupolu Raghu. Commercial Synthesis of Azilsartan Kamedoxomil: An Angiotensin II Receptor Blocker. Organic Process Research & Development. Volume 19. Issue 4. Pages 514-519. Journal; Online Computer File. (2015).

  • ROUTE 2

    • 202112072434254758.jpg

    Radl, Stanislav; Cerny, Josef; Stach, Jan; Gablikova, Zuzana. . Improved Process for Azilsartan Medoxomil: A New Angiotensin Receptor Blocker. Organic Process Research & Development. Volume 17. Issue 1. Pages 77-86. Journal; Online Computer File. (2013).

  • ROUTE 3

    • 202112077544469121.jpg

    Sangwan, Sangeeta; Panda, Tapas; Nayyar, Kaushal; Dewan, Sharwan K.; Thaper, Rajesh K. Synthesis and Characterization of Impurities of a Common and Advanced Intermediate of Candesartan and Azilsartan Antihypertensive Drugs.. International Research Journal of Pure and Applied Chemistry. Volume 5. Issue 2. Pages 1-10, 10 pp.. Journal; Online Computer File. (2015).

  • ROUTE 4

    • 202112070837191412.jpg

    Dwivedi, Shriprakash Dhar; Singh, Kumar Kamlesh; Gajera, Jitendra Maganbhai; Pandya, Jayeshkumar Mohanlal. An improved process for preparation of azilsartan medoxomil. Assignee Cadila Healthcare Limited, India. IN 2013MU01927. (2015).

  • ROUTE 5

    • 202112074980044340.jpg

    Dwivedi, Shriprakash Dhar; Singh, Kumar Kamlesh; Gajera, Jitendra Maganbhai; Pandya, Jayeshkumar Mohanlal. An improved process for preparation of azilsartan medoxomil. Assignee Cadila Healthcare Limited, India. IN 2013MU01927. (2015).

  • ROUTE 6

    • 202112072881147663.jpg

    Meng, Wenxue; Long, Daobing; Chen, Shunxiang. Method for preparing azilsartan kamedoxomil and intermediates thereof. Assignee Chongqing Landtower Pharmaceutical Co., Ltd., Peop. Rep. China. CN 105622595. (2016).

202112075251634904.jpg

Garaga, Srinivas; Misra, Nimesh C.; Raghava Reddy, Ambati V.; Prabahar, Koilpillai Joseph; Takshinamoorthy, Chandiran; Sanasi, Paul Douglas; Babu, Korupolu Raghu. Commercial Synthesis of Azilsartan Kamedoxomil: An Angiotensin II Receptor Blocker. Organic Process Research & Development. Volume 19. Issue 4. Pages 514-519. Journal; Online Computer File. (2015).

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