Benzenamine, N,5-dimethyl-2-nitro- synthesis
- Product Name:Benzenamine, N,5-dimethyl-2-nitro-
- CAS Number:65081-42-7
- Molecular formula:C8H10N2O2
- Molecular Weight:166.18
Yield:65081-42-7 97%
Reaction Conditions:
in 1-methyl-pyrrolidin-2-one;water at 20; for 5 h;
Steps:
3.A Step A: Preparation of N,5-dimethyl-2-nitroaniline
Step A: Preparation of N,5-dimethyl-2-nitroaniline: To a solution of 2-fluoro- 4-methyl-1-nitro-benzene (30 g, 193 mmol) in 1-methyl-2-pyrrolidone (50 mL) was added40% methylamine in water (50 mL, 580 mmol). The reaction mixture was stirred at ambient temperature for 5 hours. Water (300 mL) was added and the mixture was stirred at ambient temperature for 30 minutes. N,5-Dimethyl-2-nitro-aniline (31.3 g, 97%) was obtained as solid by filtration, washed with water and dried under vacuum.
References:
WO2015/175845,2015,A1 Location in patent:Paragraph 0306; 0393
578-46-1
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