Benzenemethanol, 3-chloro-, 1-acetate synthesis
- Product Name:Benzenemethanol, 3-chloro-, 1-acetate
- CAS Number:21388-93-2
- Molecular formula:C9H9ClO2
- Molecular Weight:184.62
Yield:21388-93-2 97%
Reaction Conditions:
with poly(N,N'-dibromo-N-ethylnaphthyl-2,7-sulfonamide) in neat (no solvent) at 20; for 0.116667 h;
Steps:
General Procedure for acetylation of Alcohols, Phenols, Thiol and Amine with Ac2O in the presence of PBNS under solvent-free conditions
General procedure: Alcohol, phenol, thiol or amine (1 mmol) was added to a mixture of Ac2O (2 mmol) and PBNS (30 mg), and the resulting mixture was stirred at room temperature. After completion of the reaction as monitored by TLC (nhexane/acetone: 9/1), CH2Cl2 (10 mL) was added to the reaction mixture, stirred for 1 min, and the catalyst was filtered.The precipitate was washed with CH2Cl2 (210 mL) and dried to give the recycled PBNS. Water (20 mL) was added to the filtrate and decanted. The organic layer was dried over anhydrous Na2SO4. Then, the purity of the product was checked by TLC for several times, which had only one spot related to the final product; after ensuring about that, evaporation of the solvent gave the desired pure product in good yield.
References:
Khazaei, Ardeshir;Saednia, Shahnaz;Roshani, Liela;Kazem-Rostami, Masoud;Zare, Abdolkarim [Letters in Organic Chemistry,2014,vol. 11,# 3,p. 159 - 167]
108-41-8
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