BENZO[B]THIOPHENE-2-CARBOXALDEHYDE synthesis
- Product Name:BENZO[B]THIOPHENE-2-CARBOXALDEHYDE
- CAS Number:3541-37-5
- Molecular formula:C9H6OS
- Molecular Weight:162.21
![2-METHYLBENZO[B]THIOPHENE](/CAS/GIF/1195-14-8.gif)
1195-14-8
114 suppliers
$16.00/100mg
3541-37-5
193 suppliers
$14.00/1g
Yield:3541-37-5 92%
Reaction Conditions:
with n-butyllithium in tetrahydrofuran;hexane at -78 - 20; for 2.5 h;Inert atmosphere;
Steps:
General procedure: To a stirred solution of 9he, 9hh or 9hi (200 mmol) in dried THF (200 mL) held at -78 °C in N2atmosphere was added dropwise 1.6 M n-BuLi in n-hexane (125 mL, 200 mmol) via syringe, and theresulting solution was stirred at -78 °C for 1 h ( for 9he and 9hh) or returned to room temperaturefor 5 h (for 9hi) before dropwise addition of dried DMF (21.93 g, 300 mmol) via syringe. Thereafterthe reaction mixture was stirred at -78 °C for 0.5 h and at room temperature for another 1 h. Thereaction mixture was poured into ice-water (600 mL) while stirring and the resulting mixture wasextracted with CH2Cl2 (300 mL × 3). The combined extracts were washed with 5% brine (500 mL),dried (Na2SO4) and evaporated on a rotary evaporator to give a residue, which was purified bycolumn chromatography to afford the pure product 10he, 10hh or 10hi.
References:
Cai, Wenqing;Wu, Jingwei;Liu, Wei;Xie, Yafei;Liu, Yuqiang;Zhang, Shuo;Xu, Weiren;Tang, Lida;Wang, Jianwu;Zhao, Guilong [Molecules,2018,vol. 23,# 2,art. no. 252]
![2-(HYDROXYMETHYL)BENZO[B]THIOPHENE](/CAS/GIF/17890-56-1.gif)
17890-56-1
175 suppliers
$6.00/250mg
3541-37-5
193 suppliers
$14.00/1g
95-15-8
389 suppliers
$6.00/5g
3541-37-5
193 suppliers
$14.00/1g
17890-56-1
175 suppliers
$6.00/250mg
3541-37-5
193 suppliers
$14.00/1g
6314-28-9
252 suppliers
$21.00/5g
100-68-5
359 suppliers
$9.00/1g
3541-37-5
193 suppliers
$14.00/1g