Benzoyl isothiocyanate synthesis
- Product Name:Benzoyl isothiocyanate
- CAS Number:532-55-8
- Molecular formula:C8H5NOS
- Molecular Weight:163.2
Yield:532-55-8 95%
Reaction Conditions:
with PEG-400 in dichloromethane;acetone at 20; for 2 h;
Steps:
General procedure: To a solution of benzoyl chloride (0.23 mL, 2 mmol) in CH2Cl2 (15 mL) and acetone (15 mL), KSCN(0.2 g, 2 mmol) was added at room temperature utilizing a few drops of PEG-400 as catalyst and thereaction mixture was stirred for additional 2 h. The mixture was filtrated and the filtrate was evaporatedunder reduced pressure to give benzoyl isothiocyanate (5). To a solution of 3 (1.2 g, 2 mmol) in CH2Cl2,triethylamine was added dropwise until the solution was clarified, and 6 was prepared by treating thesolution with benzoyl isothiocyanate at room temperature. The solvent was eliminated under reducedpressure to afford a crude product which was purified by column chromatography using EtOAc andpetroleum ether as the eluent.
References:
Cheng, Feng-Chang;Yin, Long;Liu, Wei-Wei;Li, Qu-Xiang;Tang, Li-Juan;Shi, Da-Hua;Cao, Zhi-Ling [Heterocycles,2015,vol. 91,# 11,p. 2113 - 2125]
333-20-0
464 suppliers
$13.50/100G
65-85-0
1484 suppliers
$10.00/25 g
532-55-8
222 suppliers
$9.00/1g
333-20-0
464 suppliers
$13.50/100G
14002-51-8
208 suppliers
$21.00/1g
532-55-8
222 suppliers
$9.00/1g
98-88-4
598 suppliers
$10.00/5g
532-55-8
222 suppliers
$9.00/1g