β-Chloro-L-alanine methyl ester hydrochloride synthesis
- Product Name:β-Chloro-L-alanine methyl ester hydrochloride
- CAS Number:17136-54-8
- Molecular formula:C4H8ClNO2.ClH
- Molecular Weight:174.03
5680-80-8
464 suppliers
$10.00/5g
17136-54-8
111 suppliers
$32.00/250mg
Yield:-
Reaction Conditions:
with thionyl chloride;sodium hydroxide in water;1,2-dichloro-ethane;N,N-dimethyl-formamide for 7 h;Reflux;Large scale;Time;
Steps:
3.2 Example 3
The 5000 kg dichloroethane pumped into the 11:50 vote plus step precipitated material was dried, and then pumped into 600 kg of thionyl chloride and dimethyl formamide 60 kg.Stirring, the reaction was heated at reflux for 7 hours heating, the exhaust gas generated by the reaction with 30% sodium hydroxide solution absorption.After completion of the reaction down to room temperature, centrifugation.The filtrate was concentrated, and concentrated to a solid for the next batch of this step applies masterbatch, distilled liquid with sodium hydroxide and dichloroethane made after the separation and reuse.
References:
Zhejiang Jiahua Chemical Co., Ltd.;Shi, Zien CN104003894, 2016, B Location in patent:Paragraph 0046