Bis(trimethylsilyl)acetylene synthesis
- Product Name:Bis(trimethylsilyl)acetylene
- CAS Number:14630-40-1
- Molecular formula:C8H18Si2
- Molecular Weight:170.4
Di(trimethylmethylsilyl)acetylene can be synthesized by the following steps:
1 With acetylene dimetallic salt and trimethyl halosilane as raw materials, acetylene dimetallic salt and trimethyl halosilane molar mass ratio of 1:2.0~1:2.2, first sus
Yield:14630-40-1 91%
Reaction Conditions:
with diethylzinc in hexane;acetonitrile at 80; for 20 h;Schlenk technique;Inert atmosphere;
Steps:
General Procedures for the Et2Zn-mediated silylation of terminal alkynes:
To a 25 mL Schlenk flask alkyne (2 mmol), chlorosilane (2 mmol), solvent (10 mL) and 1 M n-hexane solution of Et2Zn (1 mL) is added and the mixture is stirred at 80 °C for 20 h unless otherwise stated. After cooling, the reaction mixture is evaporating solvent on a rotary evaporator and analyzed with 1H NMR using CH2Br2 as an internal standard. Silica gel column chromatography with hexane/ ethyl acetate as the eluent affords the purified alkynylsilane product.
References:
Huang, Pan;Xu, Dawen;Reich, Robert M.;Kaiser, Felix;Liu, Boping;Kühn, Fritz E. [Tetrahedron Letters,2019,vol. 60,# 24,p. 1574 - 1577] Location in patent:supporting information
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