一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List BOC-SAR-OH
13734-36-6

BOC-SAR-OH synthesis

8synthesis methods
Sarcosine

107-97-1

Di-tert-butyl dicarbonate

24424-99-5

BOC-SAR-OH

13734-36-6

Triethylamine (23.5 mL, 168.3 mmol) and di-tert-butyl dicarbonate (12.9 mL, 56.1 mmol) were sequentially added to an aqueous (375 mL) solution of sarcosine (5.0 g, 56.1 mmol), and the reaction mixture was stirred for 6 hours at room temperature. After completion of the reaction, hydrochloric acid solution (320 mL, 1 M aqueous solution) and ethyl acetate were added for acidification and extraction. After separation of the aqueous layer, the aqueous layer was further extracted with ethyl acetate. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a colorless oil. The oily substance was crystallized at -15 °C to afford the target product 2-((tert-butoxycarbonyl)(methyl)amino)acetic acid (10.6 g, quantitative yield) as a white solid and a mixture of rotary isomers was observed.

-

Yield:13734-36-6 94%

Reaction Conditions:

with sodium hydride in tetrahydrofuran at 0 - 20; for 26 h;Inert atmosphere;

Steps:

Experimental procedure for the synthesisof intermediates (6a-6i)
General procedure: (S)-2-(Tert-butoxycarbonyl(methyl)amino)-3-hydroxypropanoic acid(6a) Gummy substance (This compound was prepared byadding neat sodium hydride (10 equiv.) in portion wiseover a period of 2.0 h to a cooled (0 °C) solution of (S)-2-(tert-butoxycarbonylamino)-3-hydroxypropanoic acid (1equiv.) and iodomethane (10 equiv.) in dry THF under astream of nitrogen. The reaction mixture was stirred at room temperature for 24 h under nitrogen atmosphere andthen diluted with ether (20 mL) and quenched with water(30 mL). The layers were separated and the aqueous layerwas extracted with ether (2 x9 15 mL), acidified to pH 3with a 20 % aqueous solution of citric acid and extractedwith EtOAc (3 x 20 mL). The combined organic phasewas dried over Na2SO4 and evaporated to afford thecorresponding N-methylated product in 90 % yield asGummy substance.)

References:

Srinivasarao, Kondaparla;Agarwal, Pooja;Srivastava, Kumkum;Haq;Puri, Sunil K.;Katti [Medicinal Chemistry Research,2016,vol. 25,# 6,p. 1148 - 1162]

FullText

BOC-SAR-OH Related Search:

黑水县| 盖州市| 阿城市| 阳东县| 瑞昌市| 外汇| 龙州县| 常州市| 泸西县| 达拉特旗| 名山县| 霍城县| 肃南| 永和县| 南汇区| 高碑店市| 蛟河市| 德化县| 利津县| 蒙阴县| 阳原县| 左权县| 巴青县| 高要市| 福鼎市| 长阳| 商城县| 育儿| 景谷| 天长市| 报价| 绵竹市| 揭东县| 和田市| 马尔康县| 乐陵市| 邢台市| 弥渡县| 晋宁县| 玛沁县| 宁城县|