Buspirone EP Impurity M synthesis
- Product Name:Buspirone EP Impurity M
- CAS Number:80827-62-9
- Molecular formula:C13H20BrNO2
- Molecular Weight:302.21
110-52-1
566 suppliers
$9.00/1g
1075-89-4
258 suppliers
$11.00/5g
80827-62-9
52 suppliers
$80.00/50mg
Yield:80827-62-9 75%
Reaction Conditions:
with 18-crown-6 ether;potassium carbonate in toluene at 111; for 24 h;Inert atmosphere;
Steps:
6.1. General procedure for the preparation of N-(4-bromobutyl)imides 25-28
General procedure: To the solution of an imide of general structure B in dry toluene anhydrous K2CO3 (2.5 equiv), 18-crown-6 (1 mol %) and 1,4-dibromobutane (4 equiv) were added. The reaction mixture was stirred under reflux for 24 h under inert gas. Then, the reaction mixture was filtered off and the filter cake washed with dichloromethane. The combined filtrates were evaporated under reduced pressure and crude product was distilled under reduced pressure.
References:
Jarończyk, Ma?gorzata;Wo?osewicz, Karol;Gabrielsen, Mari;Nowak, Gabriel;Kufareva, Irina;Mazurek, Aleksander P.;Ravna, Aina W.;Abagyan, Ruben;Bojarski, Andrzej J.;Sylte, Ingebrigt;Chilmonczyk, Zdzis?aw [European Journal of Medicinal Chemistry,2012,vol. 49,p. 200 - 210] Location in patent:experimental part
5662-95-3
132 suppliers
$34.00/1g
80827-62-9
52 suppliers
$80.00/50mg