C18E3 synthesis
- Product Name:C18E3
- CAS Number:4439-32-1
- Molecular formula:C24H50O4
- Molecular Weight:402.65
Yield:4439-32-1 35%
Reaction Conditions:
with sodium hydride in N,N-dimethyl-formamide at 0; for 2 h;Inert atmosphere;
Steps:
6 The general method of synthesis of P
General procedure: Under argon protection conditions,Add iodoalkane (1 eq.) to a solution of triethylene glycol or triethylene glycol (1 eq.) in DMF (40 mL).The mixture was cooled to 0 ° C,Add sodium hydride (1.5 eq. 60% in mineral oil) and stir for 2 h.Quenched with water and extracted with ethyl acetate (20 mL×2).The ethyl acetate phases were combined and washed with brine.Then dried over anhydrous sodium sulfate and concentrated to give a crude P product.Purified by silica gel column chromatography (ethyl acetate-hexane)The sample was taken immediately for the next reaction.
References:
CN110066269,2019,A Location in patent:Paragraph 0049; 0067-0069
