Carbamic chloride synthesis
- Product Name:Carbamic chloride
- CAS Number:463-72-9
- Molecular formula:CH2ClNO
- Molecular Weight:79.49
Yield:463-72-9 99%
Reaction Conditions:
in toluene
Steps:
51 6,7-Dimethoxy-N-hydroxy-N-methyl-1,2,3,4-tetrahydroisoquinoline-2-carboxamide
EXAMPLE 51 6,7-Dimethoxy-N-hydroxy-N-methyl-1,2,3,4-tetrahydroisoquinoline-2-carboxamide To 20% phosgene in toluene (30 ml) was added 6,7-dimethoxy-1,2,3,4 tetrahydroisoquinoline hydrochloride (4.6 q, 20 mmol). The mixture was heated to 75°-80° C. under nitrogen for two hours, whereupon an additional 10 ml of the 20% phosgene solution was added. After an additional two hours, a clear solution formed, which was cooled and stirred overnight. The solution was evaporated, and the residue redissolved in ether, filtered through Celite, and the filtrate evaporated to give the carbamyl chloride as a yellow oil (5.08 q, 99% yield).
References:
Ortho Pharmaceutical Corporation US5066658, 1991, A
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