Carbonochloridic acid, 1,1-diMethylethyl ester synthesis
- Product Name:Carbonochloridic acid, 1,1-diMethylethyl ester
- CAS Number:24608-52-4
- Molecular formula:C5H9ClO2
- Molecular Weight:136.58
32315-10-9
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Yield:-
Reaction Conditions:
with triethylamine in dichloromethane at 0; for 0.5 h;
Steps:
3.1.5. Synthesis of Phenyl (3-benzyl-5-hydroxyphenyl)carbamate (3a)
General procedure: To a solution of phenol (112 mg, 1.2 mmol), triphosgene (178 mg, 0.6 mmol) in CH2Cl2 (10 mL) was added dropwise triethylamine (121 mg, 1.2 mmol) at 0°C. The reaction mixture was stirred for 0.5 h and then 3-amino-5-benzylphenol 8 (119 mg, 0.6 mmol) was added. The mixture was stirred at room temperature for 5 h. After the reaction was quenched with water (30 mL), the mixture was extracted with EtOAc (10 mL×3). The combined organic layer was dried over anhydrous Na2SO4, ltered and concentrated in vacuo. The residue was puried by column chromatography (petroleum ether/EtOAc = 4:1) to afford 3a as a white solid (61 mg, 32% yield).
References:
Cheng, Ya-Juan;Liu, Zhi-Yong;Liang, Hua-Ju;Fang, Cui-Ting;Zhang, Niu-Niu;Zhang, Tian-Yu;Yan, Ming [Molecules,2019,vol. 24,# 10,art. no. 2021]
75-44-5
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865-48-5
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106-97-8
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24608-52-4
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51300-90-4
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