CBZ-D-PHENYLALANINE METHYL ESTER synthesis
- Product Name:CBZ-D-PHENYLALANINE METHYL ESTER
- CAS Number:37440-07-6
- Molecular formula:C18H19NO4
- Molecular Weight:313.35
21685-51-8
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501-53-1
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37440-07-6
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$504.50/5MG
Yield:37440-07-6 85%
Reaction Conditions:
in neat (no solvent) at 50; for 0.05 h;Microwave irradiation;Green chemistry;chemoselective reaction;
Steps:
Typical experimental procedure of N-benzyloxycarbonylation protection on amines derivatives promoted by microwave irradiation
General procedure: Benzylcholoroformate Cbz-Cl (1 mmol) was added to amine (1 mmol) and the mixture was subjected to the microwave irradiation (100W) for the appropriate time (tables 2, 3, 4 and 5). After completion of the reaction (monitored by TLC) dichloromethane: methanol (98/2), the reaction mixture was treating with n-hexane (15-20 mL) and was allowed to stand at room temperature overnight. The solid products were collected by filtration, washed with n-hexane and dried to give the N-Cbz derivatives in good to excellent yields. During the reaction, the formation of hydrogen chloride (gas) was observed, confirming the protection of all amines structures proposal.
References:
Aouf, Zineb;Mansouri, Rachida;Lakrout, Salah;Berredjem, Malika;Aouf, Nour-Eddine [Journal of the Korean Chemical Society,2017,vol. 61,# 4,p. 151 - 156]
![2-Propenoic acid, 3-phenyl-2-[[(phenylmethoxy)carbonyl]amino]-, methyl ester, (2Z)-](/CAS/20210305/GIF/130680-68-1.gif)
130680-68-1
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37440-07-6
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35909-92-3
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37440-07-6
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67-56-1
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25613-61-0
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35909-92-3
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37440-07-6
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150-30-1
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37440-07-6
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