CHEMBRDG-BB 5218790 synthesis
- Product Name:CHEMBRDG-BB 5218790
- CAS Number:83191-67-7
- Molecular formula:C10H13NO2
- Molecular Weight:179.22
17696-62-7
115 suppliers
$28.00/5g
75-31-0
439 suppliers
$14.00/25mL
83191-67-7
28 suppliers
$60.00/50mg
Yield:83191-67-7 85%
Reaction Conditions:
with hydrogenchloride in chloroform;
Steps:
1 Preparation of N-isopropyl-p-hydroxy benzamide
EXAMPLE 1 Preparation of N-isopropyl-p-hydroxy benzamide A solution composed of phenyl para hydroxy benzoate (0.0234 moles) and 15 milliliters of isopropyl amine are refluxed overnight. The excess amine is then removed via distillation at reduced pressure and the remaining oily material is dissolved in 100 milliliters of chloroform and washed first with two 50 milliliters aliquots of 6N hydrochloric acid to remove any residual amine and then with two 50 milliliter aliquots of water to remove the phenol. The solution is dried within sodium sulfate and the volume is reduced to approximately 40 milliliters. The resulting product yielded 85 percent N-isopropyl para hydroxy benezamide having a melting point of 160° to 161° C. This structure was confirmed by NMR.
References:
US4626528,1986,A
27914-73-4
22 suppliers
$63.61/250mgs:
75-31-0
439 suppliers
$14.00/25mL
83191-67-7
28 suppliers
$60.00/50mg