Yield:50386-65-7 100%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in methanol; for 4.6 h;

Steps:

A13'

[1325] A fourth intermediate compound, Chroman-5-ylamine, was produced as follows: 5-Nitro-2H-chromene (800 mg, 4.52 mmol) was hydrogenated using 10% Pd/C in MeOH (50 mL) for 4.6 h. The yellow solution turned clear. The reaction mixture was concentrated to give the fourth intermediate compound as a light brown oil which looked pure by NMR and TLC (679 mg, quant). MS: APCI: M+1: 150.3 (Exact Mass: 149.08).

References:

US2005/43309,2005,A1 Location in patent:Page/Page column 107