Chrysin synthesis
- Product Name:Chrysin
- CAS Number:480-40-0
- Molecular formula:C15H10O4
- Molecular Weight:254.24
21392-57-4
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480-40-0
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$11.00/5g
Yield:480-40-0 86%
Reaction Conditions:
with pyridine hydrochloride at 180; for 6 h;Inert atmosphere;
Steps:
Chrysin (1):
The mixture of the compound 6 (1.4 g, 0.005 mol) and excess pyridine hydrochloride (5.0 g) was heated at 180 °C for 6 h under an N2 atmosphere. Then the mixture was cooled to room temperature and H2O (100 mL) was added. The mixture was stirred for another 30 min and cooled to approximately 5 °C for several hours. The precipitate was filtered off, washed with cold ethanol and recrystallised from absolute ethanol to give a light yellow powdery (1.1 g, yield 86%);m.p. 280-284 °C (lit.16 282-285 °C); IR, ν/cm-1: 3410 (OH) 1654 (C=O);1H NMR (400 MHz, DMSO-d6), δ 6.23 (d, 1H, J = 2.0 Hz, H-6), 6.53(d, 1H, J = 2.0 Hz, H-8), 6.97 (s, 1H, H-3), 7.55-7.62 (m, 3H, H-4′,5′,6′),8.06 (m, 2H, H-2′,3′), 10.94 (s, 1H, OH-7),12.83 (s, 1H, OH-5). MS (m/z):255 [M + 1]+.
References:
Liu, Man;Zhang, Ji;Yang, Jian;Yang, Bo;Cui, Wei [Journal of Chemical Research,2014,vol. 38,# 3,p. 134 - 136]
99474-25-6
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480-40-0
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480-66-0
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98-88-4
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480-40-0
562 suppliers
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856406-49-0
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