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ChemicalBook CAS DataBase List CLOPROSTENOL LACTONE DIOL
53906-54-0

CLOPROSTENOL LACTONE DIOL synthesis

7synthesis methods
54324-79-7 Synthesis
[1,1'-Biphenyl]-4-carboxylic acid [3aR-[3aa,4a(E),5b,6aa]]-4-[4-(3-chlorophenoxy)-3-oxo-1-butenyl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester

54324-79-7
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: lithium triethylborohydride / tetrahydrofuran / 0.5 h
2: potassium carbonate / methanol; tetrahydrofuran / 2.5 h

References:

Schaaf, Thomas K.;Bindra, Jasjit S.;Eggler, James F.;Plattner, Jacob J.;Nelson, A. James;et al. [Journal of Medicinal Chemistry,1981,vol. 24,# 11,p. 1353 - 1359]

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