Cordycepin synthesis
- Product Name:Cordycepin
- CAS Number:73-03-0
- Molecular formula:C10H13N5O3
- Molecular Weight:251.24
71196-28-6
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Yield:73-03-0 87%
Reaction Conditions:
Stage #1: ((2S,4R,5R)-4-acetoxy-5-(6-amino-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl acetatewith sodium hydroxide in methanol at 25; for 1 h;
Stage #2: with ammonium chloride in methanol; for 0.5 h;Reagent/catalyst;
Steps:
5.2
(2) Basic deacylation: To a 250 mL reaction flask, 15.0 g of Compound 5-1, 150 mL of methanol and 3.9 g of sodium hydroxide solid were added, and the reaction was stirred at 25 ° C for 1 h.5.4 g of solid ammonium chloride was added, stirred for 30 min, filtered, and the filtrate was spun dry and recrystallized to give 9.8 g of Compound 1 crystals, yield 87%.
References:
CN108676048,2018,A Location in patent:Paragraph 0074-0078
2627-64-7
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![Adenosine, 3'-deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]- (9CI)](/CAS/20210305/GIF/117068-51-6.gif)
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73-03-0
496 suppliers
$12.00/5mg